Postzygotic barriers keep hybrid zygotes—one-celled embryos with parents of two different species—from developing into healthy, fertile adults. Postzygotic barriers are often related to the hybrid embryo’s mixed set of chromosomes, which may not match up correctly or carry a complete set of information.
In some cases, the chromosomal mismatch is lethal to the embryo or results in an individual that can survive but is unhealthy. In other cases, a hybrid can survive to adulthood in good health but is infertile because it can’t split its mismatched chromosomes evenly into eggs and sperm. For example, this type of mismatch explains why mules are sterile, unable to reproduce
Prezygotic and postzygotic barriers not only keep species distinct, but also play a role in the formation of new species.